DL-O-アセチルパントラクトンの結晶多形と接種法光学分割

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概要

• 論文の詳細を見る

• DL-O-Acetylpantolactone was found to have two polymorphic forms. A form is the new crystals having a melting point of 20.7° and B form is the previously reported crystals^<3)> having a melting point of 13.5°. Their racemic structure was examined from melting point diagrams, solubility diagrams, and infrared absorption spectra, and it was revealed that A form is a racemic compound and B form is a racemic congromerate. The solubilities of A and B forms in hexane were determined and thermodynamic properties of these forms were experimentally evaluated. The supersaturated solution of DL-O-acetylpantolactone was seeded with these forms and the optical isomers, and the specific rotations of the deposited crystals and the rotation angles of the filtrates were measured at appropriate time intervals. From these results, the relationship between optical resolution and racemic structures was discussed.

• 公益社団法人日本薬学会の論文
• 1977-02-25

著者

• 赤沢 修

  第一製薬株式会社研究所

• 稲垣 正博

  第一製薬株式会社研究所

• 山本 勝正

  第一製薬株式会社研究所

• 片岡 幾久江

  第一製薬株式会社研究所

関連論文

• イモノキ(タカノツメ)Evodiopanax innovans NAKAIの成分研究(第1報) : 葉からMaltolとRhoifolinの単離
• DL-O-アセチルパントラクトンの結晶多形と接種法光学分割
• Crystal Forms of Calcium D (+)-Pantothenate
• DL-O-アセチルパントラクトンの二成分系による接種法光学分割

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