DL-O-アセチルパントラクトンの二成分系による接種法光学分割

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概要

• 論文の詳細を見る

• Crystallization of DL-O-acetylpantolactone was carried out from a liquid of equimolar mixture of D- and L-O-acetylpantolactone by cooling at -10° to -20° for 5 days. From this crystallization process, it was found that the supercooled state of DL-O-acetylpantolactone was stable. The crystals obtained were confirmed to be a racemic cong1omerate by thermal analysis and infrared absorption spectrum. On the basis of these facts, the optical resolution of the crystals by seeded crystallization was examined in the binary system and successful results were obtained. As a result of the alternate D- and L-resolutions by this method, optical isomers were cbtained in 16% yield in a single cycle and their optical purity was over 80%.

• 公益社団法人日本薬学会の論文
• 1976-01-25

著者

• 稲垣 正博

  第一製薬株式会社研究所

• 国吉 家治

  第一製薬株式会社研究所

• 鍋田 三郎

  第一製薬株式会社研究所

関連論文

• イモノキ(タカノツメ)Evodiopanax innovans NAKAIの成分研究(第1報) : 葉からMaltolとRhoifolinの単離
• DL-O-アセチルパントラクトンの結晶多形と接種法光学分割
• Crystal Forms of Calcium D (+)-Pantothenate
• DL-O-アセチルパントラクトンの二成分系による接種法光学分割

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