1-β-D-Arabinofuranosylcytosineの体内分布と消化管吸収に関する研究
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概要
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Tissue distribution and gastro-intestinal absorption of tritiated 1-β-D-arabinofuranosylcytosine (AC) were investigated in rats and mice. The concentration of AC in various tissues except in brain decreased rapidly by a pseudo-first-order reaction and coincided with that in blood, while AC in the kidney was 2.5 times higher than in others. Its concentration in the brain was lower than those in other tissues and the concentration curve showed a characteristic pattern that had a peak at 2 hr after intravenous administration. Metabolites of AC were not found in the urine. The absorption of AC by its oral administration to rats was calculated from urinary excretion and was found to be approximately 6%. 1-β-D-Arabinofuranosyluracil (AU) was also present in the urine, although it was not produced in the rat tissues. It became apparent that the transformation of AC to AU occurred mainly by the intestinal microflora. In order to examine the effect of antibiotics on the absorption of AC, antibiotics were orally administered to rats and its absorption increased twice that of the control one.
- 公益社団法人日本薬学会の論文
- 1972-05-25
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