イミダゾリジノン系化合物の薬剤学的研究(第1報) : 1,2-Dimethyl-3-phenyl-4-imidazolidinoneの安定性について

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概要

• 論文の詳細を見る

• Stability of 1,2-dimethyl-3-phenyl-4-imidazolidinone (IMO-1) was examined kinetically. It was found that IMO-1 was decomposed to α-methylaminoacetanilide and acetaldehyde in acidic media by the pseudo-first order reaction. In neutral and alkaline media, these products were also formed but the equilibrium between these three compounds was readily established. The pH-profile of decomposition rate constants showed a bell-shape pattern which had a maximum value between pH 5 and 6. The reverse reaction rate was enhanced by the increase of basicity and, therefore, decomposition of IMO-1 decreased. The inflexion point of pH-profile corresponded to the pK_a value of IMO-1 (3.8) in acidic region. It was suggested that the reaction rates were influenced by the ionic nature of the compound in solution.

• 公益社団法人日本薬学会の論文
• 1971-01-25

著者

• 桂 義和

  日本新薬総合研究所

• 桂 義和

  日本新薬株式会社総合研究所

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• イミダゾリジノン系化合物の薬剤学的研究(第2報) : 1-Methyl-2-isopropyl-3-phenyl-4-imidazolidinoneおよび1-Methyl-2,3-diphenyl-4-imidazolidinoneの安定性について
• イミダゾリジノン系化合物の薬剤学的研究(第5報) : 1,2-Dimethyl-3-phenyl-4-imidazolidinoneおよび3-Phenyl-4-imidazolidinoneの血中における安定性
• イミダゾリジノン系化合物の薬剤学的研究(第3報) : 3-Phenyl-4-imidazolidinoneの安定性について
• イミダゾリジノン系化合物の薬剤学的研究(第1報) : 1,2-Dimethyl-3-phenyl-4-imidazolidinoneの安定性について

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