新鎮痛剤(-)-1,4-Dimethyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine Hydrobromide(l-ST-2121)のラット尿中代謝産物の合成とその鎮痛作用
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概要
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In order to confirm the structure of two urinary metabolites, M-I and M-II, of a new analgesic, (-)-1,4-dimethyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine hydrobromide (l-ST-2121), in rats, compounds (-)-1,4-dimethyl-9,10-dihydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine (I), (-)-1,4-dimethyl-10,11-dihydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine (II) and (-)-1-methyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine (III) were synthesized. Compounds I and III were identified with the urinary metabolites M-I and M-II, respectively. The analgesic activities and acute toxicities of I and III were examined.
- 公益社団法人日本薬学会の論文
- 1980-05-25
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関連論文
- l-1, 4-Dimethyl-10-hydroxy-2, 3, 4, 5, 6, 7,-hexahydro-1, 6-methano-1H-4-benzazonine hydrobromide (l-ST-2121)のラットにおける身体依存性試験
- 新鎮痛剤1,4-Dimethyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine Hydrobromide(ST-2121)の生体内運命(第2報)光学異性体間におけるラット尿中代謝物の比較
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