N-Alkyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine誘導体の合成

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概要

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• In order to compare the structure-activity relationship of C-homobenzomorphan derivatives with that of 6,7-benzomorphan derivatives, N-allyl ((+)-7,(-)-7,(±)-7,8), N-(3,3-dimethylallyl) ((+)-9,(-)-9,(±)-9,10) and N-cyclopropylmethyl derivatives ((+)-11,(-)-11,(±)-11,12) of (-)-1-methyl-, (+)-1-methyl-, (±)-1-methyl-and 1,12α-dimethyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methanol-1H-4-benzazonine have been synthesizad as shown in Chart 1. These compounds showed no significant analgesic activity.

• 公益社団法人日本薬学会の論文
• 1982-06-25

著者

• 塩谷 俊作

  富山大学教養部

関連論文

• N-Alkyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine誘導体の合成
• 新鎮痛剤(-)-1,4-Dimethyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine Hydrobromide(l-ST-2121)のラット尿中代謝産物の合成とその鎮痛作用
• A New Synthesis of 6,7-Benzomorphan

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