肥満細胞の機能と増殖活性におけるCyclic Adenosine 3', 5'-Monophosphateとカルシウムの役割

概要

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In many mammalian cells, cyclic adenosine 3', 5'-monophosphate (cAMP) and calcium (Ca^<2+>) served interrelated second messenger functions in the control of cellular function and growth. We have investigated; (i) the effects of cAMP and Ca^<2+> on the control of histamine release from mast cells stimulated by active oligomers, of which releases are dependent on extracellular Ca^<2+> or not. (ii) the fluctuations of cAMP levels, PGE_1-binding, and several cellular functions because of the cells respond to Bt_2cAMP, and PGE_1 with decreased growth rate and increased expression of more mature, differentiated mast cell phenotypes, and also because PGE_1 specifically binds to the cells and elevates cAMP levels. (iii) the cell cycle-dependent changes of cAMP and Ca^<2+> levels, and certain cellular functions in synchronous mastocytoma P-815 cells.
社団法人日本薬学会の論文
1984-11-25