炎症における肥満細胞の機能と環境物質の影響

概要

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Mast cells are a major cell type capable of inducing inflammation, in response to various kinds of allergens including so-called environmental substances. The present review introduces recent progress of the function of mast cells in inflammation and the effect of environmental pollunts affecting them, such as NOx, particles of oxidized metals, DDT, ultraviolet irradiation with chemicals, carcinogen and metal ions. Metal ions act on histamine release from mast cells as a stimulator (Cu^<2+>, Fe^<3+>) or an inhibitor (Zn^<2+>, Co^<2+>). Zinc ion was inhibitory in the reactions of Ca^<2+> uptake and phospholipid turn over in stimulated mast cells. The mechanism of histamine release from mast cells by a chemical agent was examined by using active oligomer of compound 48/80,a Ca^<2+>-dependent IgE type histamine releaser. Binding of oligomer to cell surface receptor induced immediate metabolism of polyphosphoinositide (degradation of PIP_2 and formation of IP_3 and DG) but it was Ca^<2+>-independent reaction. Oligomer induced Ca^<2+>-dependent accumulation of arachidonic acid into PC, PI and PA, which may be important in the formation of releasing substance and arachidonic acid-originated biological substances. Mast cells may be useful to explore the effect of environmental substances related to inflammation.
社団法人日本薬学会の論文
1986-08-31