Phenothiazine類およびPhenoxazine類の抗腫瘍性試験

概要

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Forty-eight compounds of phenothiazines, benzo [α] phenothiazines, phenoxazines, benzophenoxazines and pyrido [3,2-α] phenoxazines were prepared and their antitumor activity was examined using a solid type of Ehrlich carcinoma. The compounds which exhibited over 50% Ratio [(sample tumor weight/control tumor weight)×100] in forty-eight compounds were ten, that is, 2-chloro-5-oxo-5H-phenothiazine (4), ethopromazine hydrochloride (7), chlorpromazine hydrochloride (8), perazine dimaleate (11), fluphenazine dimaleate (12), trimeprazine tartrate (13), trimeprazine dimaleate (14), trimeprazine hydrochloride (15), 9-methyl-12H-benzo [α] phenothiazine (16) and 4-hydroxy-9-oxo-9H-benzo [α] phenoxazine (39). No other compounds were found to be high effective.
社団法人日本薬学会の論文
1983-03-25