Cetraxate Benzyl Ester Hydrochloride脱ベンジル化微生物のスクリーニングと分布(第3報)
スポンサーリンク
概要
- 論文の詳細を見る
Debenzylating enzyme catalyzes the hydrolysis of cetraxate benzyl ester hydrochloride (2) into cetraxate hydrochloride (1,antiulcer agent). Screening and distribution of the debenzylating microorganisms were undertaken to obtain microorganisms with superior debenzylating activities. Many microorganisms including yeast, bacteria, actinomycetes and fungi were found to have the ability of debenzylating 2. The order of the strength of the debenzylating activity toward 2 is fungi>bacteria>actinomycetes>yeast, and that of the hydrolyzing activity toward phenyl ester portion of 2 is actinomycetes>yeast>bacteria>fungi, on the whole. Fungi have the characteristics of secreting the debenzylating enzyme. It was suggested that Aspergillus sp. was one of the most useful microorganisms for the industrial enzymatic preparation of 1 from 2.
- 公益社団法人日本薬学会の論文
- 1990-02-25
著者
関連論文
- Cetraxate Benzyl Ester Hydrochloride脱ベンジル化微生物のスクリーニングと分布(第3報)
- Partial Purification, and Some Properties and Reactivities of Cetraxate Benzyl Ester Hydrochloride-Hydrolyzing Enzyme
- 酵素的脱ベンジル化反応で得られるCetraxateの結晶多形と結晶転換
- 酵素的脱ベンジル化反応による4'-(2-Carboxyethyl)phenyl trans-4-Aminomethyl Cyclohexane Carboxylate Hydrochloride(Cetraxate Hydrochloride)の合成