新しく単離されたRhodococcus terraeの菌体細胞壁由来糖脂質とそれらの肉芽腫形成能

概要

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Five glycolipids (GM-1,GM-2,GM-3,GM-4 and GM-5) were isolated from slightly acid-fast bacterium, Rhodococcus terrae. They were identified as trehalose dimycolate (GM-4), trehalose monomycolate (GM-5), glucose monomycolate (GM-3) and two newly isolated glycolipids (GM-1 and GM-2), respectively. Gaschromatography-mass spectrometry analysis revealed that the new glycolipids contained long-chain alcohols. Total carbon numbers of mycolic acid moieties of the glycolipids, similarly to other lipids, were ranging from C_<52> to C_<62> with three or four double bonds and C_<14> or C_<16> α-chain carbon numbers. After intravenous administration of the glycolipids to ICR mice in W/O/W emulsion, granulomatous changes were observed in the lungs and spleen, although they showed differences in potency depending on their sugar and acyl moieties. The toxicity of the glycolipids, indicated by the decline of body weights, were highly correlated to lung granuloma formation, but not to spleen granuloma formation.
社団法人日本薬学会の論文
1987-01-25