Pyrido[2,3-b]pyrazine誘導体の合成と抗菌性
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Novel pyrido[2,3-b]pyrazine 1,4-dioxide and pyrido[2,3-b]pyrazine 1-oxide derivatives were synthesized from furazano[4,5-b]pyridine 3-oxide and the enolic form of 1,3-diketones or β-ketoesters catalyzed by silica gel or molecular sieves. Their antibacterial activities were evaluated. As the results of antibacterial screening tests in vitro, pyrido[2,3-b]pyrazine 1,4-dioxide derivatives revealed strong activities, but pyrido[2,3-b]pyrazine 1-oxide derivatives revealed no activities.
- 社団法人日本薬学会の論文
- 1997-02-25
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