微生物変換研究の半世紀

スポンサーリンク

概要

• 論文の詳細を見る

• In the middle of 1950's, microbial transformation technology was introduced into the field of synthetic chemistry as a new methodology. There was a sudden interest in research on the problems of producing steroid hormones by microbial transformation. At that time, the first project entitled "The Study for Microbial Transformation of Steroids", the "Tsuda Project", was established in the Institute of Applied Microbiology (IAM), University of Tokyo, in the spring 1956,in which I took part. This paper summarizes a number of results of our microbial transformation reactions not only in the synthesis of steroidal compounds, but also more broadly for other organic compounds, such as pravastain, etc. The results are divided into five categories : 1) Microbial transformation of steroids, 2) Correlation between isolation sources of Pseudomonas spp. and their transformation activities, 3) Fermentation Production of prednisolone by Bacillus pulvifaciens SANK 71760,4) Microbial transformation of siccanin, and 5) Development and fermentation production of pravastatin. About 30 years later, almost at the end of my microbial transformation studies, I had the opportunity to find some microbial strains having superior hydroxylation ability of ML-236BNa to pravastatin. Fortunately, Streptomyces carbophilus SANK 62585 was finally selected as a potent microbial converter with the formation of a lesser amount of by-products. With the view of industrial production of pravastatin, many studies and improvements were made to the culturing conditions to obtain productivity available commercially.

• 公益社団法人日本薬学会の論文
• 2000-10-01

著者

• 内藤 敦

  八尾市立病院外科

• 内藤 敦

  三共(株)

• 内藤 敦

  三共株式会社

関連論文

• HP-073-4 乳癌センチネルリンパ節生検術中偽陰性例の検討(乳がん(センチネル2),ハイブリッドポスター,第109回日本外科学会定期学術集会)
• OP-037-3 乳癌センチネルリンパ節生検術中1個のみ転移例の検討(乳癌センチネル-3,一般口演,第110回日本外科学会定期学術集会)
• プラバスタチンの開発研究
• 254 ファジィ推論制御法によるミルベマイシンの生産培養 : 1
• 北部ラオスの米からの酒(2) : 緑色の籾酒蒸留酒
• 北部ラオスの米からの酒(1) : タイ系民族の米酒醪と蒸留酒
• 微生物変換研究の半世紀
• ラクリス・ラクボン菌 (Bacillus coagulans) の血清学的特性
• PS-164-3 進行再発消化器癌患者に対する緩和ケアチームの介入効果と今後の課題(PS-164 緩和医療,ポスターセッション,第112回日本外科学会定期学術集会)
• 土壌子のう菌類の選択的分離法から見た土壌菌と糞生菌の関係

スポンサーリンク