2-Aminoalkylpyridineをキャリヤーリガンドとする白金錯体のColon26結腸癌に対する制癌活性及び血漿蛋白質との反応性について

概要

論文の詳細を見る
The antitumor activities of (2-aminomethylpyridine)oxalatoplatinum (II) (I), (2-aminomethylpyridine) (1,1-cyclobutanedicarboxylato)platinum (II) (II), (2-(1-aminomethyl)phyridine)oxalatoplatinum(II) (III) and (2-(1-aminopropyl)pyridine)oxalatoplatinum (II) (IV) were evaluated against colon 26 carcinoma. The activity was exhibited in ip-ip system, but scarcely in sc-ip system. On the other hand, it was observed that their free platinum complexes decreased quickly in vitro when they reacted with plasma protein. From the result, it was suggested that I, II, III and IV exhibited less antitumor activity in systemic system because they formed their plasma protein complexes with no antitumor activity before reaching the cancer cell.
社団法人日本薬学会の論文
1988-08-25