Synthesis of Platinum Complexes of 2-Aminomethylpyrrolidine Derivatives for Use as Carrier Ligands and Their Antitumor Activities

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In order to study a new antitumor platinum complex, various platinum complexs were prepared from 2-aminomethylpyrrolidine derivatives synthesized to serve as carrier ligands and tested for their antitumor activity against Colon 26 carcinoma (s.c.-i.p. system) and P388 leukemia (i.p.-i.p. system) in mice. 2-Aminomethylpyrrolidine proved to be the most effective carrier ligand in its amine derivatives. The structureactivity relationships of the carrier ligands in the platinum complexes with dichloro, oxalato, 1,1-cycldutanedicarboxylato and dichlorodihydroxo as leaving group were clearly shown on the Colon 26 carcinoma screen and were as follows : the antitumor activity of the platinum complexes with any leaving groups was considerably decreased by the substitution of hydrogen by alkyl group (Me, Et) on nitrogen of aminomethyl and the effects of 1,1-cyclobutanedicarboxylato Pt(II) complexes completely disappeared with the same substitution on nitrogen of pyrrolidine. In all the tested platinum complexes 2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)platinum(II) (15) exhibited the most potent antitumor activity. 15 was superior to 1,1-cyclobutanedicarbocylatodiammineplatinum(II) (CBDCA) and similar to cis-diamminedichloroplatinum(II) (CDDP) on the Colon 26 carcinoma screen but it was inferior to CBDCA and CDDP on the P388 leukemia screen. Futhermore, 15 showed more potent antitumor activity than CBDCA against Colon 38 carcinoma (s.c.-i.p.system).
社団法人日本薬学会の論文
1990-04-25

Synthesis of Platinum Complexes of 2-Aminomethylpyrrolidine Derivatives for Use as Carrier Ligands and Their Antitumor Activities

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