アスピリン及びその関連物質の抗原性発現構造の解析

概要

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In order to elucidate the antigenicity-producing structure of aspirin and its related compounds, investigation was performed with the enzyme immunoassay (EIA) and multiple regression analysis. For the examination of the antigenic determinant of aspirin, the serum from patients with aspirin allergy was studied with EIA. As for the cross reactivity with salicylic related compounds, multiple regression analysis was made for the electron localization of salicylic acid, obtaining the following results : 1. Among the regional structures of aspirin, the salicyloyl participates in acting as the antigenic determinant, but the antigenicity of the acetyl is not recognized. 2. The antigenicity of hapten-carrier binding site reported by Haukins was not recognized clinically. 3. The cross reactivity between anti-aspirin antibody and salicylic-related compounds is dependent on the frontier electron density in the two lowest unoccupied molecular orbital of carbonyl carbon (fr^<(N)>), and the ratio of superdelocalizability of carbons in ortho-and meta-position (Sr^<(N)>o-c/Sr^<(N)>m-c).
公益社団法人日本薬学会の論文
1988-04-25