化学物質の経皮吸収と毒性 : 溶剤を中心として

概要

論文の詳細を見る
A critical factor in the evaluation of the risk associated with cutaneous exposure to chemical substances is an information relating to the percutaneous absorption of these substances. Recent developments in the percutaneous absorption of chemical substances in industry, especially organic solvents, are reviewed, and these percutaneous absorption rates in humans and animals exposed in vivo and their excised skin in vitro from vapor and liquid phase are summarized. Evaluations concerning the amounts of percutaneous absorption in vivo of organic solvents in toxicity are discussed by a mathematical model by using the percutaneous absorption coefficient for vapor phase and the percutaneous absorption rate for liquid phase, and recommendations for future research of organic solvents are proposed from the relationship between these chemical-physical properties and these percutaneous absorption rates.
公益社団法人日本薬学会の論文
1986-08-31