地域検診による重金属汚染の分析とその指標(パネルディスカッション)(第10回環境汚染物質とそのトキシコロジーシンポジウム)

概要

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Urinary total protein, β_2-microglobulin, N-acetyl-β-D-glucosaminidase activity, metallothionein and cadmium were estimated in cadmium-exposed residents and control people. There was a close relationship between urinary β_2-microglobulin concentrations and results of proximal renal tubular function tests (uric acid clearance, % TRP, renal glucosuria, generalized aminoaciduria and low molecular weight proteinuria). It was concluded that urinary β_2-microglobulin concentration was a excellent index of proximal renal tubular dysfunctions. Residents' urinary β_2-microglobulin concentrations had a close relationship with urinary cadmium concentrations, indicating Dose-Effect Relationship between cadmium exposure and its health effect (i. e, proximal renal tubular dysfunctions). The increase of N-acetyl-β-D-glucosamidase activity in urine was recognized in cadmium-exposed residents. The increase of NAG activity might appear earlier than the increase of β_2-microglobulin in urine.
公益社団法人日本薬学会の論文
1984-02-29