生薬および生薬製剤中の残留農薬について

概要

論文の詳細を見る
The residual contents of pesticides in 13 commercial crude drugs, their decoctions and 15 commercial pharmaceutical preparations which contain crude drugs were determined by using gas chromatography. Eleven kinds of organochlorine pesticides and 9 kinds of organophosphorus pesticides were examined. From the several crude drugs, 8 kinds of organochlorine pesticides were detected, but no organophosphorus pesticides were found from the crude drugs. The maximum values of BHC isomers (total BHC), DDT and related compounds (total DDT), dieldrin and heptachlor epoxide were 0.452 ppm, 0.089 ppm, 0.010 ppm and 0.039 ppm, respectively. The organochlorine pesticides in decoctions prepared from the crude drugs were found to decrease to 0-9.4% of those in the raw crude drugs. The tablets and pills containing powdered crude drugs were found to include higher amounts of organochlorine pesticides than the tablets containing the extracts of crude drugs. More than 1 ppm of total DDT was determined in the soft capsules with fish-liver oil. More than 1 ppm of total BHC and heptachlor epoxide were determined in the soft extract of Ginseng. The potential daily intakes of these pesticides from all samples were calculated. The values obtained were under 5% of acceptable daily intake (ADI) recommended by WHO.
公益社団法人日本薬学会の論文
1983-12-31