合成抗菌剤クロピドールの残留に関する研究(第2報)ブロイラーにおける体内分布, 蓄積および排泄について

概要

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After feeding broiler with a feed containing 0.0125% of clopidol (3,5-dichloro-2,6-dimethyl-4-pyridinol) in the same manner as poultry farms, the distribution and accumulation of clopidol in several organs and tissues and the excretion of clopidol into excreta were investigated. On the first day after the administration of clopidol, clopidol was very quickly distributed in all of the organs and tissues, and the amount of clopidol distributed was the highest in the liver, followed by kidney and the lowest in fat. From the first day untii the fourth week after the start of the clopidol administration, the concentration of clopidol in each organ or tissue was almost constant, liver (7.9-9.8 ppm), kidney (6.3-8.9 ppm), plasma (3.2-4.7 ppm), breast muscle (3.1-4.6 ppm), intestine (2.2-4.9 ppm), intestinal content (3.9-5.2 ppm) and fat (0.30-0.78 ppm). And the amount of clopidol found in excreta was in the range of 13.4% to 51.1% of the intake. After the stop of the clopidol administration, the concentration of clopidol in each organ or tissue decreased rapidly. It decreased below 0.01 ppm within six days in intestine and intestinal content, and within four days in other organs and tissues. The amount of clopidol in excreta decreased rapidly, too. The biological half lives of clopidol in broiler organs and tissues were found in the range of 9.7 h in liver to 32.0 h in fat.
社団法人日本薬学会の論文
1981-08-31