セレンの代謝とその生物学的役割

概要

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Selenium has two distinct faces ; one is the most toxic element regarded as one of the environmental pollutants, the other is microessential one in the nutrition of many animal species. To evaluate exactly biological roles of selenium, which are confused and controversial in the animal and human health, it is important to establish the mode of selenium metabolism and its regulation under normal and pathological conditions. This review is attempted to discuss selenium metabolism including selenium as an integral part of glutathione peroxidase molecule and its participation in the metabolisms of vitamin E, heme and other trace elements such as cadmium and mercury in mammals. Furthermore, possible biological roles of selenium in relation to the physiological status and various diseases in mammals including human being are also discussed.
公益社団法人日本薬学会の論文
1980-08-31