水銀化合物の環境衛生学的研究(第7報)妊娠ラットにおけるメチル水銀化合物の胎仔移行におよぼす2-Deoxy-D-glucoseおよびDeoxypyridoxineの影響

概要

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In order to study the mechanism of the placental transfer of methylmercury, effect of 2-deoxy-D-glucose and deoxypyridoxine on the transfer of methylmercury to the fetus across the placenta was examined. Pregnant rats were divided into three groups, group A, given 2-deoxy-D-glucose and methylmercury, group B, given deoxypyridoxine and methylmercury, group C, given methylmercury alone. Mercury content in each placenta and fetus was determined. The ratio of fetal mercury content to placental mercury content in both A and B groups was significantly lower than that in C group. It was found that 2-deoxy-D-glucose and deoxypyridoxine inhibited placental transfer of methylmercury. Therefore, it was suggested that one of the mechanisms of the placental transfer of methylmercury was an active transport which was related to amino acid having SH group such as cysteine.
公益社団法人日本薬学会の論文
1978-12-31