凍結粉砕法を前処理とした生体試料からのメチル水銀の測定に関する知見

概要

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As the pre-treatment for the determination of organic compounds in biological materials such as hair and hard tissues, freeze grinding method was found to be very useful and to have following advantages : (a) it can remarkably shorten the time necessary for grinding and extraction, (b) it is suitable for analysis of compounds unstable to heat, and (c) the size of powdered materials is small and relatively homogeneous. The particles are in the range of 5-60 μm. Methylmercury in the hair of monkeys given methylmercury chloride was determined by using this method. There were hardly any difference between the values measured just after grinding and those measured after soaking in 2N HCl solution for 24 hr. When the hair was cut with scissors, the values measured just after cutting were 1/2 to 1/4 of those measured after 24 hr soaking.
社団法人日本薬学会の論文
1978-02-28