Substitution of Zinc Bound to Metallothionein for Cadmium in Vitro and in Vivo
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概要
- 論文の詳細を見る
Rats were injected subcutaneously with cadmium (3 mg/kg) ; 5 ml of the supernatant of the liver homogenate from these animals was incubated with cadmium, and the reaction mixture was gel filtered over Sephadex G-75 column. Cadmium in vitro was mainly bound to metallothionein fraction and the amount of zinc, approximately equal to the increased amount of cadmium in metallothionein fraction, decreased. Rats pretreated subcutaneously with cadmium (3 mg/kg) were injected 2 days later intravenously with labeled cadmium (0-3 mg/kg). Almost all of the radioactivity was already bound to metallothionein fraction after 30 min. The ratio of cadmium to zinc both bound to two different types of metallothionein fractionated by gel filtration and ion exchange chromatography increased in proportion to the amount of cadmium additionally injected. These findings indicate that the zinc bound to metallothionein is substituted with cadmium both in vivo and in vitro.
- 公益社団法人日本薬学会の論文
- 1977-08-31
著者
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Tanaka Keiichi
Department Of Toxicology Graduate School Of Pharmaceutical Sciences Osaka University:(present Office
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Onosaka Satomi
Department Of Nutrition Kobe-gakuin University
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Onosaka Satomi
Department Of Public Health Faculty Of Nutrition Kobe-gakuin University
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Doi Masako
Department Of Public Health Faculty Of Nutrition Kobe-gakuin University
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OKAHARA KUNIO
Department of Public Health, Faculty of Nutrition, Kobe-Gakuin University
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Okahara Kunio
Department Of Public Health Faculty Of Nutrition Kobe-gakuin University
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Tanaka Keiichi
Department Of Emergency And Critical Care Medicine Fukuoka University Hospital
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Tanaka Keiichi
Department Of Anatomy Tottori University School Of Medicine
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