Molecular Mechanism of the Metallothionein Gene Expression Mediated by Metal-Responsive Transcription Factor 1

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概要

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• Metal-responsive transcription factor 1(MTF-1) is essential for activating transcription of the metallothionein genes in response to multiple species of heavy metals by binding to the metal-responsive element(MRE) located in the upstream region of the genes. In contrast, MTF-1 binding to the MRE in vitro is induced only by zinc ions, suggesting that MTF-1 acts as a zinc sensor protein. Although the mechanism allowing such a zinc-responsive factor to respond to various metal species in vivo remains ambiguous, recent information regarding the metal response of MTF-1 and the genes expressed downstream of MTF-1 provides important clues to unraveling the intrinsic mechanism and the biological significance of the MTF-1 functions in vivo.

• 公益社団法人日本薬学会の論文
• 2001-12-01

著者

• Otsuka Fuminori

  Department Of Environmental Toxicology Faculty Of Pharmaceutical Sciences Teikyo University

• Otsuka Fuminori

  Department Of Toxicology And Environmental Health Faculty Of Pharmaceutical Sciences Teikyo Universi

関連論文

• A Human Mental Responsive Element-Binding Protein Interacts With a Homologous Element of the Mouse Metallothionein-I Gene
• Detection of Metallothioneins in Polyacrylamide Gels by Silver Staining
• Nuclear Proteins Binding to the Human Metallothionein-II Gene Upstream Sequences
• Transcriptional Regulation of the Metallothionein Genes
• Molecular Mechanism of the Metallothionein Gene Expression Mediated by Metal-Responsive Transcription Factor 1

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