Transcriptional Regulation of the Metallothionein Genes

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概要

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• The classical mammalian metallothioneins (MT-I/II) and the other subfamilies (MT-III/IV) both bind heavy metals by the well-conserved cysteine cluster structure, but their modes of expression differ from each other. MT-I/II is ubiquitously induced by heavy metals, but MT-III/IV is expressed in restricted tissues without obvious dependency on heavy metals. To understand the heavy metal dependent transcriptional activation of the MT-I/II genes, the mechanism of the heavy metal response of a pivotal transcription factor, MTF-1, has been extensively studied. On the other hand, in the case of MT-III, the mechanism of gene suppression has been investigated to clarify the basis of its tissue specific expression. In this review, recent progress in understanding the transcriptional regulation of these MT subfamilies is described.

• 公益社団法人日本薬学会の論文
• 2004-08-01

著者

• Otsuka Fuminori

  Department Of Environmental Toxicology Faculty Of Pharmaceutical Sciences Teikyo University

• Otsuka Fuminori

  Department Of Molecular Environmental Health Faculty Of Pharmaceutical Sciences Teikyo University

関連論文

• A Human Mental Responsive Element-Binding Protein Interacts With a Homologous Element of the Mouse Metallothionein-I Gene
• Detection of Metallothioneins in Polyacrylamide Gels by Silver Staining
• Nuclear Proteins Binding to the Human Metallothionein-II Gene Upstream Sequences
• Transcriptional Regulation of the Metallothionein Genes
• Molecular Mechanism of the Metallothionein Gene Expression Mediated by Metal-Responsive Transcription Factor 1

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