Effects of Zinc and Copper on Uptake of Cadmium by LLC-PK_1 Cells

スポンサーリンク

概要

• 論文の詳細を見る

• Effects on zinc (Zn) and copper (Cu) on cadmium (Cd) accumulation were investigated in LLC-PK_1 cells. Coincubation with Zn or Cu decreased Cd uptake by the cells in a concentration-dependent manner. Cd accumulation data suggested that Cd is taken up by the cells via simple diffusion and carrier-mediated transport. Zn and Cu significantly increased the K_m of Cd uptake with no or little effect on the V_<max>. Pretreatment of the cells with ouabain and a metabolic inhibitor (FCCP) significantly decreased Cd accumulation, and coincubation with Zn or Cu led to an additional decrease in Cd accumulation by these cells. Overall, it seems that, in addition to simple diffusion, Cd is also taken up by LLC-PK_1 cells via carrier-mediated mechanisms that are competitively inhibited by Zn and Cu.

• 公益社団法人日本薬学会の論文
• 1996-07-15

著者

• Endo T

  Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• Endo Tetsuya

  北海道薬科大学

• Sakata M

  Department Of Applied Chemistry And Biochemistry Faculty Of Engineering Kumamoto University

• Kimura O

  Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• Endo Tetsuya

  Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• KIMURA Osamu

  Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido

• SAKATA Masakatsu

  Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido

• Sakata Masakatsu

  Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• Kimura Osamu

  Department Of Agricultural Sciences Faculty Of Agriculture Okayama University

• Sakata M

  Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

関連論文

• A case of HIV co-infected with hepatitis B virus precore/core deletion mutant treated by entecavir
• Evaluation of an Estimation of Physiologic Ability and Surgical Stress (E-PASS) Scoring System to Predict Postoperative Risk : A Multicenter Prospective Study
• Preparations and Applications of Polyethyleneimine-Immobilized Cellulose Fibers for Endotoxin Removal
• A case of severe recurrent hepatitis with common variable immunodeficiency
• Inactivation of Blasticidin S by Bacillus cereus. VI. Structure and Comparison of the bsr Gene from a Blasticidin S-Resistant Bacillus cereus
• Nucleotide Sequence of the bsr Gene and N-Terminal Amino Acid Sequence of Blasticidin S Deaminase from Blasticidin S Resistant Eshcerichia coli TK121(Biological Chemistry)
• Cloning and Expression of a New Structural Gene for Blasticidin S Deaminase, a Nucleoside Aminohydrolase(Biological Chemistry)
• The Transport of Ciprofloxacin in Cultured Kidney Epithelial Cells LLC-PK_1
• Limulus Amebocyte Lysate Assay for Endotoxins by an Adsorption Method with Polycation-immobilized Cellulose Beads
• Uptake of Cd-Metallothionein into LLC-PK_1 Cells : A Comparative Study with CdCl_2
• Effects of Zinc and Copper on Uptake of Cadmium by LLC-PK_1 Cells
• Studies on Intestinal Absorption of Sulpiride (2) : Transepithelial Transport of Sulpiride Across the Human Intestinal Cell Line Caco-2(Biopharmacy)
• Studies on Intestinal Absorption of Sulpiride (1) : Carrier-Mediated Uptake of Sulpiride in the Human Intestinal Cell Line Caco-2
• Investigation of Vasodilatory Substances in Diesel Exhaust Particles (DEP) : Isolation and Identification of Nitrophenol Derivatives
• Isolation of Nitrophenols from Diesel Exhaust Particles (DEP) as Vasodilatation Compounds
• Estrogenic Activities of Chemicals in Diesel Exhaust Particles
• RAPID DETERMINATION OF CARBOXYHEMOGLOBIN BY ABSORBANCE DIFFERENCE BETWEEN DOUBLE WAVE LENGTH
• Pore-Size Controlled and Aminated Poly(γ-methyl L-glutamate) Particles for Selective Removal of Nucleic Acids
• Partially Hydrophobized Polymer Particles Derived from N, N-Dimethylaminopropylacrylamide for Endotoxin Removal from Acidic Protein Solution
• DETERMINATION OF CARBON MONOXIDE IN BLOOD BY HEAD SPACE ANALYSIS
• Anti-estrogenic Activity of Diesel Exhaust Particles
• TOXICITY OF D, L-MANDELONITRILE-β-D-GLUCOSIDE, "PRULAURASIN" IN RAT.
• TOXICITY OF GASEOUS SUBSTANCES
• Ascorbate Oxidase in Cucumber Calli and Enhancement of Enzyme Activity by Copper Sulfate
• Purification and Properties of Ascorbate Oxidase from Cucumber Fruit
• Protoplast Formation from Schizophyllum commune by a Culture Filtrate of Bacillus circulans KA-304 Grown on a Cell-wall Preparation of S. commune as a Carbon Source
• Alternative or Simultaneous Electrochemical Access with Micro Water/Oil Phases in a Middle Phase Microemulsion Based on the Hydrophilic/Lipophilic Balance on Electrode Surfaces
• Selective Permeation of Nitric Oxide through Two Dimensional Cross-linked Polysiloxane LB Films
• Electrochemistry in Middle Phase Microemulsion Composed of Saline and Toluene with Sodium Dodecylsulfate and n-Butanol
• Adsorption-Induced Self-Organization of Calix[4]arene on Au(111) Surfaces
• Characterization of Dendritic Polymer-Modified Porous Silica Particles Using Size Exclusion Chromatography
• Effect of pK_a of Polymer Microcarriers on Growth of Mouse L Cell
• In situ STM Visualization of Fullerene Epitaxial Adlayers on Au (III) Surfaces Prepared by the Transfer of Langmuir Films
• Characterization of the epithelial cell adhesion molecule (EpCAM)^+ cell population in hepatocellular carcinoma cell lines
• Bowel function after surgery for anorectal malformations in patients with tethered spinal cord
• Selective Removal of Endotoxin from a DNA Solution by Cross-linked Cyclodextrin Beads
• Mechanisms of Cadmium Uptake by LLC-PK_1 Cells
• 培養腎上皮細胞LLC-PK_1とOKの刷子縁膜におけるカドミウムの輸送機構について
• Levels of Mercury and Organohalogen Compounds in the Muscle and Liver of Kidako Moray Eels (Gymnothorax kidako) Caught off the Southern Region of Japan
• 3,3',4,4'-Tetrachlorobiphenyl-Mediated Decrease of Serum Thyroxine Level in C57BL/6 and DBA/2 Mice Occurs Mainly through Enhanced Accumulation of Thyroxine in the Liver

もっと見る 閉じる

スポンサーリンク