Effect of Carnitine on Decrease of Branched Chain Amino Acids and Glutamine in Serum of Septic Rats
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概要
- 論文の詳細を見る
Blood concentrations of branched chain amino acids (BCAA ; leucine, isoleucine, and valine) and glutamine (Gln) decrease markedly in sepsis. We investigated the effect of carnitine on serum concentrations of BCAA and Gln in fasted septic rats. Rats were made septic by cecal ligation and puncture. They developed extremely high blood concentrations of endotoxin, and serum concentrations of BCAA and Gln were markedly decreased 2 d after the operation. When L-carnitine was administered subcutaneously to the rats at 500 mg/kg body weight every 12 h for 2 d starting at the operation, no decrease in the serum concentrations of BCAA and Gln was observed. This indicates that the administration of carnitine can prevent the decrease of serum concentrations of BCAA and Gln in septic animals.
- 公益社団法人日本薬学会の論文
- 1996-01-15
著者
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TAKESHITA Yasuyoshi
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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Yamakawa M
Tokyo Univ. Tokyo Jpn
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HAYASHI Naoki
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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YOSHIHARA Daiji
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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KASHIWABARA Norio
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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HANDA Harumi
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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YAMAKAWA Mitsuru
3rd Department of Surgery, University of Tokyo
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Handa H
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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Yoshihara Daiji
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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Takeshita Yasuyoshi
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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Kashiwabara Norio
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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Hayashi Naoki
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
関連論文
- Protective Effect of Administration of Skim Milk on Exogenous and Endogenous Infection in Mice
- Effect of Carnitine on Decrease of Branched Chain Amino Acids and Glutamine in Serum of Septic Rats
- New Immobilization Method of Mammalian Cells Using Alginate and Polyacrylate
- Beneficial Effects of Enteral Fat Administration on Liver Dysfunction, Liver Lipid Accumulation, and Protein Metabolism in Septic Rats.