Inhibitory Effect of Ginseng Total Saponins on Glutamate-Induced Swelling of Cultured Astrocytes

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概要

• 論文の詳細を見る

• The effects of ginseng total saponins (GTS) on L-glutamate-induced swelling of cultured astrocytes from rat brain were studied. Following exposure to 0.5 mM glutamate for 1 h, the intracellular water space (as measured by [^3H] O-methyl-D-glucose uptake) of astrocytes increased three-fold with a morphological change : the disappearance of cellular processes. Simultaneous addition of GTS with glutamate reduced the astrocytic swelling in a dose-dependent manner. GTS at 0.5 mg/ml did not affect the viability of astrocytes for up to 18 h, which was determined by a colorimetric assay for cellular growth and survival. These data suggest that GTS prevents the cell swelling of astrocytes induced by glutamate.

• 公益社団法人日本薬学会の論文
• 1995-12-15

著者

• 馬場 明道

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University

• SEONG YeonHee

  College of Veterinary Medicine, Chungbuk National University

• SHIN ChangSik

  College of Pharmacy Chungbuk National University

• KIM HackSeang

  College of Pharmacy Chungbuk National University

• Seong Yeonhee

  College Of Veterinary Medicine Chungbuk National University

関連論文

• Anti-complementary Activity of Ursane-Type Triterpenoids from Weigela subsessilis(Pharmacognosy)
• Inhibitory Effect of Ginseng Total Saponins on Glutamate-Induced Swelling of Cultured Astrocytes
• CENTRALLY MEDIATED HYPERGLYCEMIA BY 6-AMINONICOTINAMIDE
• EFFECT OF VARIOUS NUCLEOTIDES AND DRUGS ON MICROSOMAL THIAMINE DIPHOSPHATASE ACTIVITY IN RAT BRAIN

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