Pharmacokinetics of Propranolol and Its Metabolites in Horses after Intravenous or Oral Administration

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概要

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• The pharmacokinetics characteristics of propranolol (PPL) in horses was studied by administering the drug intravenously or orally to the animals. The predominant primary pathway was ring oxidation, and 4-hydroxypropranolol glucuronide (4-OHPG) was the major metabolite in both plasma and urine. Side-chain glucuronidation and oxidation were not significant. A two-compartment model was employed for PPL followed by a one-compartment model for 4-OHPG. After oral administration, one-step absorption and two-step first pass metabolism were employed. The fraction absorbed of PPL was approximately 70% after oral administration, and the bioavailability varied among individual horses from 1 to 79% depending on the first pass metabolism. The biologic half-life (T_<1/2>) of PPL obeys the allometric equation in some animal species including rats and horses, except for human. T_<1/2> of PPL in horses was approximately 2 h.

• 公益社団法人日本薬学会の論文
• 2000-11-01

著者

• Koizumi T

  Toyama Medical And Pharmaceutical University

• Koizumi Tamotsu

  Toyama Medical And Pharmaceutical University

• Mori Miwako

  Laboratory Of Racing Chemistry

• ARAMAKI Sugako

  Laboratory of Racing Chemistry

• Shinohara Tatsumi

  Laboratory of Protein Chemistry and Engineering Genetic Resources, Graduate School of Genetic Resour

• NAKATA Masayuki

  Laboratory of Racing Chemistry

• Aramaki S

  Laboratory Of Racing Chemistry

• Nakata M

  Laboratory Of Racing Chemistry

• Shinohara Tatsumi

  Laboratory Of Racing Chemistry

• Shinohara Tatsumi

  Laboratory Of Protein Chemistry And Engineering Genetic Resources Graduate School Of Genetic Resourc

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• Purification of Chymotrypsin Inhibitors from Larval Hemolymph of the Silkworm, Bombyx mori
• Pharmacokinetics of Propranolol and Its Metabolites in Horses after Intravenous or Oral Administration
• Theoretical Relationship between the Post-administration Time and Plasma or Urinary Concentration of a Metabolite and the Unchanged Drug. Administration of Caffeine to Horses

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