Influence of Verapamil and Digoxin on the in Vitro Binding of Doxorubicin to the Rat Heart

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概要

• 論文の詳細を見る

• A study has been carried out to characterize the binding of doxorubicin to hear homogenates and subcellular fractions. The technique chosen to perform the study was equilibrium dilalysis and the levels of anthracycline in the samples obtained from the dialysis were assessed using HPLC. Doxorubicin has high affinity to heart homogenates and subcellular fractions such as nuclear, mitochondrial and microsomal. The binding was saturable and dose-dependent. Doxorubicin binding is decreased in the presence of digoxin and especially verapamil.

• 公益社団法人日本薬学会の論文
• 1998-08-15

著者

• Alvarez-cedron Loreto

  Department Of Pharmacy And Pharmaceutical Technology University Of Salamanca

• LOPEZ Francisco

  Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Salamanca

• LANAO Jose

  Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Salamanca

• Lanao Jose

  Department Of Pharmacy And Pharmaceutical Technology University Of Salamanca

• Lopez F

  Univ. Salamanca Salamanca Esp

• Lopez Francisco

  Departamento De Geometria Y Topologia Facultad De Ciencias Universidad De Granada

関連論文

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• Pharmacokinetic Study of the Digoxin-acenocoumarol Interaction in Rabbits
• A Computer Program (DCN) for Numerical Convolution and Deconvolution of Pharmacokinetic Functions
• Influence of Verapamil and Digoxin on the in Vitro Binding of Doxorubicin to the Rat Heart

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