Determination of Uric Acid in Scalp Hair for Non-Invasive Evaluation of Uricemic Controls in Hyperuricemia
スポンサーリンク
概要
- 論文の詳細を見る
The uric acid concentration in blood has been widely accepted as a diagnostic indicator of hyperuricemia and gout, and its assay method is well established. In the present study, we developed a simple and rapid method for the determination of uric acid in hair, which can be obtained non-invasively. The concentration (nmol/mg hair) of uric acid extracted from 10-20 mg hair with 0.1 M potassium hydroxide was determined by an enzymatic method using uricase. The concentration of uric acid (nmol/mg hair, mean±S.D. : 0.49±0.157,n=16) in hair from hyperuricemic patients was significantly higher than that (0.26±0.107,n=8) in healthy volunteers (p<0.01). The within-run and between-day precision (CVs) of the assay was 9.6-10.3% (n=10 each) and 11.6-16.3% (n=7 each), respectively. The concentration (nmol/mg hair, y) of uric acid in hair correlated well with that in serum (mg/l, x) : y=0.09x-0.12 (r=0.75,S_<yx>=0.122,n=23). Changes in the concentration of uric acid in the hair of antihyperucemic drug-treated patient paralleled that in serum, suggesting that the concentration of uric acid in hair is a reliable indicator of the metabolic control in hyperuricemia.
- 公益社団法人日本薬学会の論文
- 1998-04-15
著者
-
Tsubakihara Yoshiharu
Department Of Kidney Disease And Hypertension Osaka General Medical Center
-
Isaka Yoshitaka
Discovery Research Laboratories 1 Shionogi & Co. Ltd.
-
Isaka Yoshitaka
First Department Of Internal Medicine School Of Medicine Osaka University
-
KOBAYASHI Kunio
Diagnostic Science Division, Shionogi & Co., Ltd.,
-
MORIOKA Yasuhide
Diagnostic Science Division, Shionogi & Co., Ltd.,
-
Isaka Yoshitaka
Department Of Advanced Technology Of Transplantation Osaka University Graduate School Of Medicine
-
Morioka Yasuhide
Diagnostic Science Division Shionogi & Co. Ltd.
-
Morioka Yasuhide
Diagnostic Science Department Shionogi & Co. Ltd.
-
Kobayashi Kunio
Diagnostic Science Department Shionogi & Co. Ltd.
-
Kobayashi Kunio
Diagnostic Science Division Shionogi & Co. Ltd.
関連論文
- Negative effects of anemia on quality of life and its improvement by complete correction of anemia by administration of recombinant human erythropoietin in posttransplant patients
- Pharmacokinetics of olmesartan medoxomil in hemodialysis patients : little effect of dialysis upon its pharmacokinetics
- Serum Osteoprotegerin as a Screening Tool for Coronary Artery Calcification Score in Diabetic Pre-Dialysis Patients
- Effect of Renin-Angiotensin-Aldosterone System Triple Blockade on Non-Diabetic Renal Disease : Addition of an Aldosterone Blocker, Spironolactone, to Combination Treatment with an Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker
- Prevalence of human polyoma virus (BK virus and JC virus) infection in patients with chronic renal disease
- Carbonic adsorbent AST-120 retards progression of renal failure by additive effect with ACEI and protein restriction diet
- Deoxyspergualin, an immunosuppressant, in patients suffering from nephropathies with crescent formation : an open-label trial to evaluate safety and efficacy
- Cyclosporin A Mono-therapy in Nephrotic Syndrome with Contra-indication of Steroid Therapy
- Pregnancy after renal transplantation : A single-center experience
- evidence-based practice guideline for the treatment of chronic kidney disease
- Design and methods of a strategic outcome study for chronic kidney disease : Frontier of Renal Outcome Modifications in Japan
- Utility of the Japanese GFR estimation equation for evaluating potential donor kidney function
- Discrepancy between serum levels of low molecular weight proteins in acute kidney injury model rats with bilateral ureteral obstruction and bilateral nephrectomy
- Exercise-induced acute kidney injury with reversible posterior leukoencephalopathy syndrome
- Post-transplant lymphoproliferative disorder following renal transplantation : A single-center experience over 40 years
- 2 Mineral and Bone Disorder in Cardio-renal Interaction(The Mechanism and Management of Cardio-renal Risk,Roundtable Discussion 3 (RT-3) (H),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Determination of Uric Acid in Scalp Hair for Non-Invasive Evaluation of Uricemic Controls in Hyperuricemia
- Construction of the Chimeric Reverse Transcriptase of Simian Immunodeficiency Virus Sensitive to Nonnucleoside Reverse Transcriptase Inhibitor
- Targeting of Chrolamphenicol Acetyltransferase to Human Immunodeficiency Virus Particles via Vpr and Vpx
- Determination of Sulfate-Conjugated 3β-Hydroxy Bile Acid in Urine by HPLC with Postcolumn Fluorescence Detection Using an Immobilized β-Hydroxysteroid Dehydrogenase Column
- Colorimetric Determination of Cystine (Disulfide Bond) in Hair Using Dithiothreitol
- An autopsy-proven case of myeloperoxidase-antineutrophil cytoplasmic antibody-positive polyarteritis nodosa with acute renal failure and alveolar hemorrhage
- CD28 superagonist-induced regulatory T cell expansion ameliorates mesangioproliferative glomerulonephritis in rats
- Glycation Index of Hair for Non-invasive Estimation of Diabetic Control
- Effects of nicorandil on the reduction of BNP levels in patients with chronic kidney disease
- Tubulointerstitial nephritis and uveitis syndrome with transient hyperthyroidism in an elderly patient
- Towards developing new strategies to reduce the adverse side-effects of nonsteroidal anti-inflammatory drugs
- Cigarette smoking and chronic kidney diseases
- Safety and efficacy of administering the maximal dose of candesartan in renal transplant recipients
- Performance of the Japanese GFR equation in potential kidney donors
- Gene polymorphisms contributing to hypertension in immunoglobulin A nephropathy