Reduction in Blood Free Carnitine Levels in Association with Changes in Sodium Valproate (VPA) Disposition in Epileptic Patients Treated with VPA and Other Anti-epileptic Drugs
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概要
- 論文の詳細を見る
Reduction in the blood free carnitine (FC) level as a side effect of sodium valproate (VPA) given epiletic patients was pharmacokinetically studied in connection with changes in the VPA disposition. The serum FC level in patients taking at least one of phenobarbital (PB), phenytoin (PHT) and/or carbamazepine (CBZ) in addition to VPA was significantly lower than that in the controls given only these other anti-epileptic drugs (AEDs). Patients medicated only with VPA also tended to have a lower serum FC level than the controls, although the difference was not significant. Among all the patients taking VPA with or without other AED(s), a significantly positive correlation was observed between the serum FC level and the value of dose and level ratio (L/D) of VPA, indicating that both the serum FC concentration and the L/D value of VPA were remarkably reduced in those patients receiving both medications. These results suggested that reduction in the blood FC level as a side effect of VPA reflected FC deficiency associated with the accelerated degradation of VPA in liver; such a condition appears to result from medication with VPA and other AED(s) which induce(s) enzyme(s) for the VPA metabolism.
- 公益社団法人日本薬学会の論文
- 1997-01-15
著者
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Hiraoka Atsushi
愛媛県立中央病院 消化器内科
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Hiraoka Atsushi
Kyorin Univ. Tokyo Jpn
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荒戸 照世
杏林大学医学部生化学
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荒戸 照世
杏林大・医・眼科
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荒戸 照世
杏林大・医・第二生化
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荒戸 照世
国立医薬品食品衛生研究所医薬品医療機器審査センター
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TOMINAGA Itaru
Department of Psychiatry, National Hospital Organization Shimofusa Psychiatric Medical Center
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Tominaga Itaru
National Hospital Organizations Shimohusa Psychiatric Medical Center
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Tominaga I
National Chiba Hospital Chiba Jpn
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Arato Teruyo
Department of Biochemistry, Kyorin University School of Medicine
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Hiraoka Atsushi
Department Of Gastroenterology Ehime Prefectural Central Hospital
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Arato T
Department Of Biochemistry Kyorin University School Of Medicine
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Arato Teruyo
Department Of Biochemistry Kyorin University School Of Medicine
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Arato Teruyo
Pharmaceuticals And Medical Devices Agency
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Tominaga Itaru
Department Of Clinical Research National Shimofusa Hospital
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Hiraoka Atsushi
The Third Department Of Internal Medicine Ehime University School Of Medicine
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