Synthesis and Pharmacological Activities of 2-(3'-substituted-2'-hydroxypropylamino)pyridines

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概要

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• In the present study, a series of 2-(3'-substituted-2'-hydroxypropylamino)pyridines were synthesized and characterized by IR, ^1H-NMR and elemental analysis. The compounds were investigated for anticonvulsant(150, 300 mg/kg)and cardiac activity. 2-(3'-Diethylamino-2'-hydroxypropylamino)pyridine 3 was found to exhibit the highest anticonvulsant activity. 2-(3'-Dimethylamino-2'-hydroxypropylamino)pyridine 2 and 2-[3'-(4"-nitrophenyl- amino)-2'-hydroxypropylamino]pyridine 6 were found to exhibit negative ionotropic aetivity. 2-(3'-Dimethylamino-2'-hydroxypropylamino)pyridine 2, 2-[3'-(4"-nitrophenylamino)-2'-hydroxypropylamino]pyridine 6 and 2-(3'-piperidino-2'-hydroxypropylamino)pyridine 8 were found to antagonize exhibit β-adrenergic activity.

• 公益社団法人日本薬学会の論文
• 2002-02-01

著者

• Thomas Leonard

  Department Of Pharmaceutical Chemistry And Pharmacology Vel's College Of Pharmacy Old Pallavara

• Kishore Gnanasam

  Department Of Medicinal Chemistry And Pharmacology Vel's Colleg Of Pharmacy Old Pallavaram

• Sridhar S

  Department Of Pharmaceutical Chemistry C. L. Baid Metha College Of Pharmacy

• Sadish Kumar

  Department Of Medicinal Chemistry And Pharmacology Vel's Colleg Of Pharmacy Old Pallavaram

• SRIDHAR Seshaiah

  Department of Pharmaceutical Chemistry and Pharmacology, Vel's College of Pharmacy

• ANBALAGAN Navaneetharaman

  Department of Pharmaceutical Chemistry, C. L. Baid Metha College of Pharmacy

• Thomas Leonard

  Department Of Medicinal Chemistry And Pharmacology Vel's Colleg Of Pharmacy Old Pallavaram

• Leonard Joseph

  Department Of Medicinal Chemistry And Pharmacology Vel's College Of Pharmacy

• Anbalagan Navaneetharaman

  Department Of Medicinal Chemistry And Pharmacology Vel's Colleg Of Pharmacy Old Pallavaram

関連論文

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• Synthesis and Pharmacological Activities of 2-(3'-substituted-2'-hydroxypropylamino)pyridines
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