Synthesis and Pharmacological Activities of Hydrazones, Schiff and Mannich Bases of Isatin Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
Schiff bases and phenyl hydrazone of isatins were prepared by reacting isatin and the appropriate aromatic primary amine/hydrazines. A new series of the corresponding N-mannich bases were synthesized by reacting them with formaldehyde and diphenylamine. The chemical structures were confirmed by means of their ^1H- NMR, IR spectral data and elemental analysis. The compounds were screened for analgesic, antiinflammatory and antipyretic activity. 1-Diphenylaminomethyl-3-(1-naphthylimino)-1, 3-dihydroindol-3-one(4), 3-(1-naph-thylimino)-5-bromo-1, 3-dihydroindol-2-one (2)and 1-diphenylaminomethyl-3-(4-methylphenylimino)-1, 3-dihy-droindol-3-one(7)were found to exhibit the highest analgesic, anti-inflammatory and antipyretic activity respectively. 1-Diphenylaminomethyl-3-(4-methylphenylimino)-1, 3-dihydroindol-3-one(7)was found to be the most active compound of the series.
- 公益社団法人日本薬学会の論文
- 2001-10-01
著者
-
Sridhar Seshaiah
インド
-
SRIDHAR Seshaiah
Department of Pharmaceutical Chemistry and Pharmacology, Vel's College of Pharmacy
-
Ramesh Atmakuru
Department Of Pesticide Chemistry Fredrick Institute Of Plant Protection And Toxicology
-
Ramesh Atmakuru
Department Of Analytical Chemistry Mass Spectrometry Division International Institute Of Biotechnolo
関連論文
- Electron ionization gas chromatography-mass spectrometric determination of residues of thirteen pyrethroid insecticides in whole blood
- Synthesis and Pharmacological Activities of 1,8-Naphthyridine Derivatives
- Synthesis and Pharmacological Activities of 2-(3'-substituted-2'-hydroxypropylamino)pyridines
- Synthesis and Biological Activities of 2,6-Diaryl-3-methyl-4-piperidone Derivatives
- Synthesis, Antiviral and Cytotoxic Activity of 6-Bromo-2,3-disubstituted-4(3H)-quinazolinones(Medicinal Chemistry)
- Synthesis and Pharmacological Activities of Hydrazones, Schiff and Mannich Bases of Isatin Derivatives