ENTEROHEPATIC CIRCULATION OF CLIOQUINOL IN THE RAT
スポンサーリンク
概要
- 論文の詳細を見る
The existence of the enterohepatic circulation (EHC) of clioquinol was confirmed by using paired rats, donor and recipient, which were connected to each other with a bile duct-to-duodenum cannula. The concentrations of clioquinol and its metabolites appearing in the plasma of the recipient following intraduodenal 10 mg/kg dose of clioquinol to the donor were fairly low. However, within 24h after the administration ca. 12% of the dose was reexcreted in the bile of the recipient as clioquinol glucuronide and ca.2% in the urine as clioquinol sulfate. From these results and the data of biliary excretion in our previous paper, the glucuronide was found to play a role on the EHC. Further, both in vitro and in situ results suggested that clioquinol glucuronide excreted in the bile may be absorbed partially after return to the parent drug in the intesinal tract and partially as such without deconjugation.
著者
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TAMURA ZENZO
Hospital Pharmacy
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NAKAGAWA FUJIO
Hospital Pharmacy, Faculty of Medicine, University of Tokyo
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KOTAKI Hajime
Hospital Pharmacy, Faculty of Medicine, University of Tokyo
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Kotaki Hajime
Hospital Pharmacy Faculty Of Medicine University Of Tokyo
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Tamura Zenzo
Keio University Hospital Pharmacy
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Saitoh Yukiya
Faculty Of Medicine University Of Tokyo
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Nakagawa Fujio
Hospital Pharmacy Faculty Of Medicine University Of Tokyo
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Nakagawa Fujio
Faculty Of Medicine University Of Tokyo
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SAITOH Yukiya
Hospital Pharmacy, Faculty of Medicine, University of Tokyo
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Saiton Yukiya
Hospital Pharmacy Faculty Of Medicine University Of Tokyo
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Tanimura Yuichi
Hospital Pharmacy Faculty Of Medicine University Of Tokyo
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YAMAMURA YOSHIKAZU
Hospital Pharmacy, Faculty of Medicine, University of Tokyo
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Yamamura Yoshikazu
Hospital Pharmacy Faculty Of Medicine University Of Tokyo
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KOTAKI Hajime
Department of Pharmacy, The Research Hospital, The Institute of Medical Science, The University of Tokyo
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