The Biological Fate of Sodium Prasterone Sulfate after Vaginal Administration. I. Absorption and Excretion in Rats

概要

論文の詳細を見る
The absorption and excretion of sodium prasterone sulfate (PS) (sodium dehydroepiandrosterone sulfate) were studied in rats after vaginal administration of ^<14>C-PS. In late pregnant rats, maximum plasma level (C_<max>) appeared at 2-4h after dosing and both C_<max> and the area under the plasma concentration-time curve (AUC) increased proportionally with increased dose up to 4.0mg/kg. The radioactivity administered was almost completely recovered from urine and feces during a 72h postdosing period. The percentages of radioactivity excreted in urine and feces were 58% and 40% of the dose, respectively. The biliary excretion was 46% of the dose within 48h and about half of the radioactive biliary excreta entered the enterohepatic circulation system. The vaginal absorption of PS was markedly affected by the estrous cycle stage and the progress of pregnancy. The vaginal absorption of PS was predominant at metestrus and diestrus and during late pregnancy.
公益社団法人日本薬学会の論文