Isolation and Identification of the New Metabolites of 1-[Bis (4-fluorophenyl)-methyl]-4-(2,3,4-trimethoxybenzyl) piperazine Dihydrochloride (KB-2796) from Rat Bile, Urine and Feces
スポンサーリンク
概要
- 論文の詳細を見る
The metabolites of 1-[bis (4-fluorophenyl) methyl]-4-(2,3,4-trimethoxybenzyl) piperazine dihydrochloride (KB-2796) in the bile, urine and feces in rats were investigated after oral administration of [methine-^<14>C], [benzyl-^<14>C] and unlabelled KB-2796. Their structures were characterized by thin-layer chromatography, mass spectrometry, proton nuclear magnetic resonance and comparison with synthesized authentic compounds. The main pathways of biotransformation of KB-2796 in rats were : (a) O-demethylation at each methoxy group of the trimethoxybenzyl moiety, (b) N-dealkylation at 1 and 4-position of the piperazine ring and (c) hydroxylation at 5-position of the 2,3,4-trimethoxyphenyl ring.
- 公益社団法人日本薬学会の論文
著者
-
Awata Norio
Product R & D Laboratories Pharmaceuticals Research Center
-
Awata Norio
Product Research And Development Laboratories Pharmaceuticals Research Center Kanebo Ltd.
-
KAWASHIMA Tsuneo
Product R & D Laboratories, Pharmaceuticals Research Center
-
Kawashima T
Kanebo Ltd. Osaka Jpn
-
SATOMI Osamu
Product Research and Development Laboratories, Pharmaceuticals Research Center, Kanebo, Ltd.
-
Satomi Osamu
Product Research And Development Laboratories Pharmaceuticals Research Center Kanebo Ltd.
関連論文
- Pharmacokinetics of an Antiallergic Agent, 1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-1H-benzimidazole Difumarate (KG-2413) after Oral Administration : Interspecies Differences in Rats, Guinea Pigs and Dogs
- Binding of 1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1,4-diazepin-1-yl) benzimidazole Difumarate (KG-2413) to Serum or Plasma Proteins in Man, Guinea Pig and Rat
- The Biological Fate of Sodium Prasterone Sulfate after Vaginal Administration. I. Absorption and Excretion in Rats
- Isolation and Identification of the New Metabolites of 1-[Bis (4-fluorophenyl)-methyl]-4-(2,3,4-trimethoxybenzyl) piperazine Dihydrochloride (KB-2796) from Rat Bile, Urine and Feces
- VAGINAL ABSORPTION OF SODIUM PRASTERONE SULFATE AND HUMAN CALCITONIN