In Vitro Study on Corneal Permeability to Bunazosin

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概要

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• Corneal permeability of bunazosin, one of the alpha-adrenergic receptor antagonists, was investigated in vitro using excised rabbit cornea mounted on a corneal permeability apparatus, and the enhancing effects of various acids on the permeability of bunazosin were evaluated. Caprylic and capric acid elevated octanol/water partition coefficient of bunazosin, and corneal permeability was increased, probably as a result of ion-pair formation between them. Neither bunazosin, these acids, or the ion-pair caused corneal swelling. These acids, in contrast, had little effect on the partition of pilocarpine, or on corneal permeability.

• 公益社団法人日本薬学会の論文

著者

• Iwata S

  Tsukuba Research Laboratories Eisai Co. Ltd.:department Of Biophysical Chemistry Faculty Of Pharmace

• Iwata Shuzo

  Tsukuba Research Laboratories Eisai Co. Ltd.:department Of Biophysical Chemistry Faculty Of Pharmace

• Kato A

  Tohoku Univ. Sendai Jpn

• Kato Akira

  Tsukuba Research Laboratories Eisai Co. Ltd.

関連論文

• Studies on Improved Corneal Permeability to Bunazosin
• Corneal Permeability to Bunazosin in Rabbits
• In Vitro Study on Corneal Permeability to Bunazosin

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