ANTITUMOR ACTIVITY OF 13-METHYL-BERBERRUBINE DERIVATIVES

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概要

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• The antitumor activity of several 13-alkyl-berberrubine and newly synthesized ester derivatives, using experimental tumors (S-180,NF sarcoma, Ehrlich carcinoma and L-1210) in mice was tested. For chemotherapeutic evaluation, the therapeutic indices and ratios were determined. Our present findings confirmed that in berberrubine derivatives, the 9-demethyl structure was essential for the manifestation of antitumor activity and demonstrated that ester derivatives also exhibit a remarkable antitumor activity, and the 13-methyl derivatives of both berberrubine and palmatrubine alkaloids showed high antitumor activity.

• 公益社団法人日本薬学会の論文

著者

• IKEKAWA TETSURO

  National Cancer Center Research Institute

• IKEDA YOSHIAKI

  National Cancer Center Research Institute

関連論文

• STUDIES ON ANTITUMOR POLYSACCHARIDES OF FLAMMULINA VELUTIPES (CURT. EX FR.) SING.II. THE STRUCTURE OF EA_3 AND FURTHER PURIFICATION OF EA_5
• ANTITUMOR ACTIVITY OF 13-METHYL-BERBERRUBINE DERIVATIVES

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