CHANGE IN KINETIC PROPERTIES AND METABOLIC CLEARANCE OF UDP-GLUCURONYLTRANSFERASE FOR P-PHENYL BENZOIC ACID IN DEVELOPING FETUS OF RAT

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概要

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• The hepatic microsomal UDP-glucuronyltransferase (UDPGT) for p-phenyl benzoic acid (PPBA) in the developing fetus of rat was investigated. The kinetic properties of UDPGT in microsome of fetus changed during developmental period. The value of the V_<max> for PPBA and uridine 5'-phosphoglucuronic acid (UDPGA) per mg protein increased with the day of gestation, remarkably between the 19th and 21st day of gestation. The developmental profile of the V_<max> per g liver was similar to the V_<max> per mg protein. Whereas the V_<max> in whole liver showed repid increase during development comparing with the V_<max> per g liver. The K_m for PPBA and UDPGA showed slower increase with the day of gestation than the corresponding V_<max>.

• 公益社団法人日本薬学会の論文

著者

• Nanbo Toshio

  Tokai Laboratories Daiichi Pure Chemicals Co. Ltd.

関連論文

• CHANGE IN KINETIC PROPERTIES AND METABOLIC CLEARANCE OF UDP-GLUCURONYLTRANSFERASE FOR P-PHENYL BENZOIC ACID IN DEVELOPING FETUS OF RAT
• Influence of para Substituent of Phenol on Phospholipid Dependence of Uridine Diphosphate-glucuronyltransferase
• CHANGE IN PHARMACOKINETIC CHARACTER OF p-PHENYL BENZOIC ACID IN DEVELOPING FETUS OF RAT
• STUDIES ON THE ABSORPTION MECHANISM FOR THE GLUCURONIDE OF p-PHENYL BENZOIC ACID IN FETAL COMPARTMENT
• PHARMACOKINETICS IN MATERNAL-FETAL UNIT AFTER INTRAVENOUS ADMINISTRATION OF p-PHENYL BENZOIC ACID TO RAT
• RELATIONSHIP BETWEEN UDP-GLUCURONOSYLTRANSFERASE ACTIVITY AND MICROSOMAL ENVIRONMENT
• DEVELOPMENTAL CHANGE IN CLEARANCE OF GLUCURONIDE OF p-PHENYLBENZOIC ACID FROM IN VITRO KINETIC PARAMETERS AND ITS CORRELATION WITH CLEARANCE FROM IN VIVO IN FETUS OF RAT
• METABOLIC STUDIES ON METIAZINIC ACID I ABSORPTION, DISTRIBUTION, EXCRETION AND METABOLISM IN RATS AND RABBITS

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