SAFRAMYCIN S, A NEW SAFRAMYCIN GROUP ANTIBIOTIC
スポンサーリンク
概要
- 論文の詳細を見る
Saframycin S, structurally the decyano-saframycin A and biosynthetically the precursor of saframycin A, is a new antibiotic and is assumed to be the active principle for the formation of the antibiotic-DNA complex to manifest its activity. In the present study on the biological activity of saframycin S, the antibiotic showed a marked activity against Ehrlich ascites tumor with the doses of 0.5 to 0.75 mg/kg/day for 10 days, and the rate of 40-day survivors was 80 to 90%. However, this antibiotic was less effective against P388 leukemia than saframycin A at the doses tested. Saframycin S also showed the highest antimicrobial activity, in particular against gram-positive bacteria, among the saframycin group antibiotics identified to date. The LD_<50> of saframycin S was 3.2 mg/kg (i.p.) for ddY mice. The biological activity and toxicity of saframycin S in relation to its structure were described.
- 社団法人日本薬学会の論文
著者
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ARAI Tadashi
Department of Obstetrics and Gynecology, Tokai University School of Medicine
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Arai Tadashi
Department Of Obstetrics And Gynecology Tokai University School Of Medicine
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Mikami Yuzuru
Department Of Antibiotics Research Institute For Chemobiodynamics Chiba University
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YOKOYAMA KOJI
Department of Antibiotics, Research Institute for Chemobiodynamics, Chiba University
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TABETA HIROSHI
Department of Antibiotics, Research Institute for Chemobiodynamics, Chiba University
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NAKAGAKI KAZUHIDE
Department of Antibiotics, Research Institute for Chemobiodynamics, Chiba University
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Tabeta Hiroshi
Department Of Antibiotics Research Institute For Chemobiodynamics Chiba University
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Yokoyama Koji
Department Of Antibiotics Research Institute For Chemobiodynamics Chiba University
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Nakagaki Kazuhide
Department Of Antibiotics Research Institute For Chemobiodynamics Chiba University
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Arai Tadashi
Department Of Antibiotics Research Institute For Chemobiodynamics Chiba University
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Nakagaki Kazuhide
Department Of Animal Science Nippon Veterinary Life Science University Medical Research Laboratories
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