EFFECTS OF CS-386 AND DIAZEPAM UPON THE GASTRIC CONTRACTION AND EXCITATION OF LUMBAR GAMMA-MOTO-NEURONS FOLLOWING STIMULATION OF THE HYPOTHALAMUS IN THE CAT

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概要

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• Effects of a new minor tranquilizer, CS-386 and diazepam were studied upon the gastric contraction and excitation of lumbar gamma-motoneurons following stimulation of some of the brain structures as well as upon the spontaneous gastric motility in the cat. CS-386 inhibited the hypothalamus-induced gastric contraction with little changes in spontaneous motility at doses of 5 and 10 mg/kg (i. d.). Diazepam inhibited both the hypothalamus-induced contraction and spontaneous motility at these doses. The vagal nerve-induced gastric contraction was suppressed by diazepam (5 mg/kg, i. d.) but not by the same dose of CS-386. Bemegride (5 mg/kg, i. v.) antagonized almost completely the depression caused by 5 mg/kg of CS-386,but not that by a dose of 10mg/kg or 5 as well as 10mg/kg of diazepam. Excitation of the lumbar gamma-motoneuron following stimulation of the posterior hypothalamus or the mesencephalic reticular formation was depressed by CS-386 or diazepam (10mg/kg, p. o.), but not by lower doses. Based on these evidences, it was suggested that CS-386 could be effective in stress-induced gastric lesions with lower side effects in digestive organs than diazepam.

著者

• KOBAYASHI Kazuo

  Central Laboratory, Kirin Brewery Co.

• IWATA Nobuyoshi

  Neuroscience and Immunology Research Laboratories, Sankyo Co., Ltd.

• TONOHIRO Toshiyuki

  Neuroscience and Immunology Research Laboratories, Sankyo Co., Ltd.

• Hara T

  Department Of Environmental Physiology Faculty Of Medicine Shimane University

• Iwata Nobuyoshi

  Neuroscience And Immunology Research Laboratories Sankyo Co. Ltd.

• Tonohiro Toshiyuki

  Neuroscience And Immunology Research Laboratories Sankyo Co. Ltd.

• IWATA NOBUYOSHI

  Central Research Laboratories, Sankyo Co.

• HARA TAKAO

  Central Research Laboratories, Sankyo Co.

• TONOHIRO TOSHIYUKI

  Central Research Laboratories, Sankyo Co.

• SHIBATA TAKASHI

  Central Research Laboratories, Sankyo Co.

• Kobayashi Kazuo

  Biological Research Laboratories Sankyo Co.

• Shibata Takashi

  Central Research Laboratories Sankyo Co.

• Kobayashi Kazuo

  Central Laboratories For Key Technology Kirin Brewery Co. Ltd.

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