DAMAGE OF CULTURE CELLS BY S-ADENOSYL-3-THIOPROPYLAMINE

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概要

• 論文の詳細を見る

• S-Adenosyl-3-thiopropylamine (ATPA) damaged all three cell lines examined. The toxic effect was dependent on the kind of serum added in the culture medium. The serum dependency was closely related to the monoamine oxidase activity in the serum. ATPA was significantly oxidized in the calf serum which is rich in the enzyme activity. Detection of acrolein, a potent cytotoxic aldehyde, from incubation mixtures containing ATPA and calf or horse serum supported a hypothesis that release of acrolein from oxidized ATPA may be responsible for the toxic effect of ATPA.

• 公益社団法人日本薬学会の論文

著者

• SAMEJIMA KEIJIRO

  Tokyo Biochemical Reserch Institute

• KAWASE MASAKO

  Tokyo Biochemical Reserch Institute

• OKADA MASASHI

  Tokyo Biochemical Reserch Institute

• Shibuta Hiroshi

  Department Of Viral Infection Institute Of Medical Science University Of Tokyo

• Okada Masashi

  Tokyo Biochemical Research Institute

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