The Shell Dissolution of Various Empty Hard Capsules

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概要

• 論文の詳細を見る

• The shell dissolution properties of gelatine, gelatine/polyethylene glycol (PEG) and hydroxypropyl methylcellulose (HPMC) capsules were studied as a function of temperature, dissolution medium, and after different storage conditions. In any dissolution medium with a pH below or equal to 5.8,HPMC capsule shells dissolved rapidly, and there was no difference in the time in which dissolution occurred in the tested temperature interval of 10 to 55℃. Gelatine and gelatine/PEG capsule shells, generally, did not dissolve at temperatures below 30℃. The shell dissolution time of all capsules tested was prolonged and more variable in mixed phosphate buffer pH=6.8. The addition of enzymes (pepsin, pancreatin) to any dissolution medium was found not to enhance the differences between the different types of capsules investigated. In practical terms, the results indicated that capsule formulations should not be taken with drinks from the carbonated Cola-type. Gelatine containing capsules should preferably be administered with a warm drink, whereas HPMC capsules could be given with cold or warm drinks. The latter type of capsules should also be preferred for preparations to be taken in the fasted state. A short storage of gelatine containing capsules under hot humid tropical conditions appeared not to alter the dissolution properties of the shells, and changes in disintegration times and dissolution times of formulations filled in such capsules might be a reflection of changes of the powders incorporated rather than of the capsule shells. However, a short storage of HPMC capsules under such conditions appeared to influence the capsule shell matrix.

• 社団法人日本薬学会の論文
• 2000-07-01

著者

• Jones Brian

  Shionogi Qualicaps S.a.

• CHIWELE Irene

  Department of Pharmaceutics, The School of Pharmacy, University of London

• PODCZECK Fridrun

  Department of Pharmaceutics, The School of Pharmacy, University of London

• Chiwele Irene

  Department Of Pharmaceutics The School Of Pharmacy University Of London

• Podczeck Fridrun

  Department Of Pharmaceutics The School Of Pharmacy University Of London

関連論文

• The Shell Dissolution of Various Empty Hard Capsules
• Adhesion and Autoadhesion Measurements of Micronized Particles of Pharmaceutical Powders to Compacted Powder Surfaces
• The Development of a Cascade Impactor Simulator Based on Adhesion Force Measurements to Aid the Development of Dry Powder Inhalations

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