Adhesion and Autoadhesion Measurements of Micronized Particles of Pharmaceutical Powders to Compacted Powder Surfaces

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概要

• 論文の詳細を見る

• Micronized samples of lactose monohydrate and salmeterol xinafoate have been used to study the adhesion of micronized particles to compacted powder surfaces. After an initial increase in median adhesion force with increased press-on force no further increase in median adhesion force can be achieved. Thus application of larger press-on forces eventually appears to result in a maximum plastic deformation of the micronized particles. This is in contrast to previous experiments using particles of the same materials in a size range between 20 and 120 μm, where an increase in press-on force always led to an increase in median adhesion force.The adhesion of micronized lactose monohydrate particles to salmeterol xinafoate surfaces is numerically higher than the adhesion of micronized salmeterol xinafoate particles to lactose monohydrate surfaces, although theoretically the same two materials are adhered to each other. This effect could be due to differences in the surface roughness of the compacted surfaces. Hence, if a true estimate of adhesion is required from adhesion studies of any two materials, either material should be used as particlate and as compacted powder material. Otherwise a careful consideration of the practical conditions which are to be modelled has to be made to choose the most appropriate system.The relative autoadhesion force of micronized lactose monohydrate particles could have been predicted from the results obtained using larger particles. This is valid with small limitations also for the relative antoadhesion force of salmeterol xinafoate. The relative adhesion force of salmeterol ximafoate particles to compacted lactose monohydrate surfaces appears independent of particles size even into micronized size range if particles with similar morphology are compared.

• 公益社団法人日本薬学会の論文
• 1995-11-15

著者

• Podczeck Fridrun

  Department Of Pharmaceutics The School Of Pharmacy University Of London

• Newton John

  Department Of Pharmaceutics The School Of Pharmacy University Of London

• James Michael

  Glaxo Research & Development Ltd.

関連論文

• The Shell Dissolution of Various Empty Hard Capsules
• Adhesion and Autoadhesion Measurements of Micronized Particles of Pharmaceutical Powders to Compacted Powder Surfaces
• The Development of a Cascade Impactor Simulator Based on Adhesion Force Measurements to Aid the Development of Dry Powder Inhalations

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