Efficient Synthesis of a Key Intermediate of DV-7751 via Optical Resolution or Microbial Reduction

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概要

• 論文の詳細を見る

• Two efficient and practical methods of synthesis of the C-10 substituent of DV-7751 (1), a novel quinolone carboxylic acid, were established. The first method utilizes an optical resolution of racemic 8-amino-6-benzyl-6-azapiro[3.4]octane (13), while the second employs an enantioselective microbial reduction of 6-benzyl-5,8-dioxo-6-azaspiro[3.4]octane (8b). The enantiomeric excess of (S)-8-amino-6-benzyl-6-azaspiro[3.4]octane (11) with each method of synthesis is greater than 96%.

• 公益社団法人日本薬学会の論文
• 2000-04-01

著者

• Satoh K

  Chemical Technology Research Laboratories Daiichi Pharmaceutical Co. Ltd.

• MIYADERA Akihiko

  Chemical Technology Research Laboratories, Daiichi Pharmaceutical Co., Ltd.,

• SATOH Koji

  Chemical Technology Research Laboratories, Daiichi Pharmaceutical Co., Ltd.,

• IMURA Akihiro

  Chemical Technology Research Laboratories, Daiichi Pharmaceutical Co., Ltd.,

• Imura A

  Chemical Technology Research Laboratories Daiichi Pharmaceutical Co. Ltd.

• Miyadera A

  Chemical Technology Research Laboratories Daiichi Pharmaceutical Co. Ltd.

関連論文

• Efficient Synthesis of a Key Intermediate of DV-7751 via Optical Resolution or Microbial Reduction
• An Efficient Synthesis of a Key Intermediate of DU-6859a via Asymmetric Microbial Reduction
• Purification, Properties and Reactivity of the Esterase form Micrococcus sp.
• Enantioselective Synthesis of a Key Intermediate of 20(S)-Comptothecin via and Enzyme-Catalyzed Resolution

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