Enantioselective Synthesis of a Key Intermediate of 20(S)-Comptothecin via and Enzyme-Catalyzed Resolution

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概要

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• The key intermediate of a 20(S)-camptothecin 1 synthesis was obtained in a highly enantioselective fashion using an enzyme-catalyzed resolution. A commercially available protease was found to exhibit the highest enantioselectivity with moderate activity, and (S)-ethyl 2-acetoxy-2[6-(acetoxymethyl)-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-7-yl]butanoate 7c of 98% e.e. was obtained as the remaining substrate.

• 公益社団法人日本薬学会の論文
• 1998-12-15

著者

• Itoh M

  Chemistry Laboratory Research Center Mochida Pharmaceutical Co. Ltd.

• MIYADERA Akihiko

  Chemical Technology Research Laboratories, Daiichi Pharmaceutical Co., Ltd.,

• IMURA Akihiro

  Chemical Technology Research Laboratories, Daiichi Pharmaceutical Co., Ltd.,

• Imura A

  Chemical Technology Research Laboratories Daiichi Pharmaceutical Co. Ltd.

• ITOH Motohiro

  Chemical Technology Research Laboratories, Daiichi Pharmaceutical Co., Ltd.,

• Miyadera A

  Chemical Technology Research Laboratories Daiichi Pharmaceutical Co. Ltd.

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• Purification, Properties and Reactivity of the Esterase form Micrococcus sp.
• Enantioselective Synthesis of a Key Intermediate of 20(S)-Comptothecin via and Enzyme-Catalyzed Resolution

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