Synthesis of 15α-Fluoro-24,25-dihydrolanosterol as a Potential Inhibitor and/or Mechanistic Probe for Lanosterol 14α-Demethylase

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概要

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• As a potential inhibitor and/or mechanistic probe for lanosterol 14α-demethylase, 15α-fluoro-24,25-dihydrolanosterol was prepared by fluorination of 15α-hydroxy-24,25-dihydrolanost-7-en-3β-yl benzoate with diethyl-aminosulfur trifluoride, followed by hydrogen chloride-catalyzed isomerization of the Δ^7 to Δ^8 and reductive cleavage of the benzoate.

• 公益社団法人日本薬学会の論文
• 2000-10-01

著者

• MORISAKI Masuo

  Kyoritsu College of Pharmacy

• Yamamoto Satomi

  Kyoritsu College Of Pharmacy

• MORISAK Masuo

  Kyoritsu College of Pharmacy

• IGATA Tomoko

  Kyoritsu College of Pharmacy

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• Synthesis of 15α-Fluoro-24,25-dihydrolanosterol as a Potential Inhibitor and/or Mechanistic Probe for Lanosterol 14α-Demethylase

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