The Inclusion Compounds of β-Cyclodextrin with 4-Substituted Benzoic Acid and Benzaldehyde Drugs Studied by Proton Nuclear Magnetic Resonance Spectroscopy

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概要

• 論文の詳細を見る

• Inclusion compounds of some 4-substituted benzoic acid and benzaldehyde drugs with β-cyclodextrin were prepared and characterized by IR spectroscopy, powder X-ray diffraction, thermogravimetry, and ^1H-NMR spectroscopy. The thermal stability and chemical stability of these drugs were strikingly improved after inclusion. The effect of inclusion on the chemical-shifts of protons H-3 and H-5 in the NMR spectroscopy is discussed. Using the relative shift theory, the preferred inclusion mode was proposed. The center of the aromatic ring of the drug molecule was considered to be located in the cavity 1.2Å inside from the H-5 plane of β-cyclodextrin.

• 公益社団法人日本薬学会の論文
• 2000-01-01

著者

• Lu C‐s

  Nanjing Univ. Nanjing Chn

• LU Chang-Sheng

  Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University

• HU Chuan-Jiang

  Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University

• MENG Qing-Jin

  Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University

• Meng Qing-jin

  Coordination Chemistry Institute State Key Laboratory Of Coordination Chemistry Nanjing University

• Hu Chuan-jiang

  Coordination Chemistry Institute State Key Laboratory Of Coordination Chemistry Nanjing University

• Lu Chang-sheng

  Coordination Chemistry Institute State Key Laboratory Of Coordination Chemistry Nanjing University

• YU Yan

  Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University

• Yu Y

  Hunan Normal Univ. Changsha Chn

関連論文

• The Inclusion Compound of a New Ionizable Derivative of β-Cyclodextrin with Ferrocenium Drug
• An Antitumor Agent of β-Cyclodextrin-Modified Titanocene Complex: Synthesis and Characterization
• The Inclusion Compounds of β-Cyclodextrin with 4-Substituted Benzoic Acid and Benzaldehyde Drugs Studied by Proton Nuclear Magnetic Resonance Spectroscopy

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